The artemisin based-therapeutic combinations (ATC) are an approach developed to solve the malaria parasite chemo-resistance problem in endemic area. The aim of this study is to evaluate the factors associated to the weak proportion of children under the age of 5 years treated with the ATC against malaria. The data collected on a sampling of 9177 treated children in 13 health centers in Gbado-Lite city in 2014 have been analyzed with the help of Epi-info software package (version 3.5.4). The number of children treated with the ATC is weak (58.9%) in spite of the availability in ATC (87.7%). The socio-demographic factors and the life styles of the ATC prescribers are not associated to the weak proportion of the children treated with ATC (p>0.5). Nevertheless, a strong non-significant association is observed with alcohol consumption by the prescribers of ATC (p>0.72). A weak non-significant association is noted in male (p=0.52) and with the seniority of the prescribers (p=0.71). The factors like age, marital status, monthly income, study level, lodging and consumption of tobacco are not associated with the weak proportion of children treated with ATC. The influence of the number of staffs working in the health centers on the proportion of children treated with ATC is variable according to the considered structures of health. It is therefore desirable to develop advantage of the strategies for a rational prescription in order to guarantee a better malaria treatment in children at Gbado-Lite city.