Chromolaena odorata, an invasive plant of the Asteraceae family, is widespread in Africa, particularly in Côte d’Ivoire, where it poses significant challenges to agricultural systems by competing with crops for essential resources. However, this plant also offers ecological and agronomic benefits when integrated into sustainable agricultural practices. It can enrich soils with essential nutrients, such as calcium, and promote soil alkalinization. Additionally, its dense biomass helps control weeds and prevent soil erosion. These underutilized characteristics warrant further investigation into its integration within sustainable agriculture. To this end, an agronomic trial was conducted in Daloa to assess the impact of C. odorata biomass on maize cultivation. Four treatments were tested in a Fisher block design: (i) C. odorata alone (Co), (ii) C. odorata with standard mineral fertilizer (CoNPK), (iii) standard mineral fertilizer alone (NPK), and (iv) a control with no treatment (T0). The results showed that the C. odorata alone treatment yielded the highest grain outputs, closely followed by the use of standard mineral fertilizer. In contrast, the control treatment produced the lowest yields, and the combination of C. odorata and mineral fertilizers resulted in yields lower than those from C. odorata alone. It is recommended to integrate C. odorata as a biofertilizer in sustainable agricultural systems due to its economic and ecological benefits. Further studies are required to define an optimal technical pathway for its use, assess its long-term effects on soils, and determine its potential to enhance crop profitability.