This study was conducted to explore the perceptions of street children regarding the consumption of toxic substances in the city of Bunia. The research employed an ethnographic approach and was supported by semi-structured interviews and focus groups. It involved a sample of 42 children. Data analysis was performed using content analysis techniques and thematic framework development. The study revealed that street children mentioned various types of toxic substances they use, including paste, alcohol, gasoline, cannabis, Valium (diazepam), and cigarettes. They also cited different reasons for their substance use, such as forgetting past events and avoiding thoughts of their parents. Additionally, the children identified several risks associated with substance use, including lung disease, liver disease, heart disease, and death. Therefore, it is crucial to consider implementing strict measures to prohibit substance use among these children, as it poses significant health risks.