Introduction: COVID-19 remains associated with high morbidity and mortality among patients admitted to intensive care units (ICUs), particularly in resource-constrained settings. Identifying factors associated with mortality and analyzing time to death are essential to improve clinical management and inform prevention strategies. This study aimed to analyze survival among ICU patients with COVID-19 and to identify factors associated with mortality. Methods: This was an observational analytical study including patients admitted to the ICU for COVID-19. Total ICU length of stay (DTS), expressed in days, was used as the time variable. Death in the ICU was considered the event of interest, while patients discharged alive or transferred were treated as censored observations. Survival probabilities were estimated using the Kaplan–Meier method with calculation of medians and 95% confidence intervals. Survival comparisons were performed using the log-rank test. Bivariate logistic regression was used to estimate odds ratios (ORs), followed by a multivariable Cox proportional hazards model to identify factors independently associated with mortality. Results: A total of 175 patients were included, with an overall mortality rate of 65.7%. The median overall survival was 6 days. In bivariate analysis, age ≥ 60 years (OR = 2.45; 95 % CI [1,30 –4,60]), unvaccinated status (OR = 2.10; 95 % CI [1,15 –3,85]), and diabetes (OR = 1.80; 95 % CI [1,00 –3,20]) were significantly associated with mortality. The use of invasive mechanical ventilation was strongly associated with death (OR = 10.5; 95 % CI [4,8 –23,0]). In multivariable analysis, age, vaccination status, and type of ventilatory support remained independently associated with mortality. Conclusion: This study highlights a high and early mortality among patients admitted to the ICU for COVID-19. Advanced age, lack of vaccination, diabetes, and severe respiratory failure requiring invasive mechanical ventilation were the main determinants of poor prognosis. These findings underscore the importance of preventive strategies, particularly vaccination, and early, appropriate management of severe COVID-19 to reduce ICU mortality.

Introduction: The objective of the study is to investigate the factors associated with trachoma in the Diourbel Health District (HD) in Senegal in 2019. Methodology: This is a cross-sectional, descriptive, and analytical study conducted in June 2019 among households in the Diourbel HD. It was a two-stage random sample survey. Data were collected during an individual interview after free and informed consent. Logistic regression was used to identify factors associated with trachoma. Results: 3544 individuals aged 1 year to 9 years and 3402 individuals aged 15 years and older, respectively in the active trachoma (AT) and trachomatous trichiasis (TT) components were surveyed. Among the 1-9 year olds, 1973 individuals or 55.7% of the respondents were less than 5 years old. 1864 individuals or 52.6% were female. The prevalence of BP was 2.0% [1.5%-2.5%]. Among those aged 15 years and over, 2250 individuals or 66.1% of the respondents were aged 15-44 years. 2498 individuals or 73.4% of the respondents were female. The prevalence of TT was 1.6% [1.1%-2.0%]. Among 1-year-olds to 9-year-olds, the age range 3 years to 4 years: ORA= 2.66 [1.31-5.41] and latrine outside the home: ORA= 17.73 [4.01-78.36] were significantly associated with BP. In the 15+ age group, the age groups 45-64 years: ORA= 17.79 [6.82- 46.37], 65-74 years: ORA= 22.9 [7.98- 65.69], and 75+ years: ORA= 18.83 [5.9- 60.14] were significantly associated with TT. Conclusion: The Diourbel HD validated the WHO criteria for elimination of BP, but TT still remains a public health problem. The risk factors associated with TT were age and latrine outside the home. The risk factor associated with TT was age. Thus, in order to obtain the certificate of elimination of trachoma in the Diourbel Health District by 2024, the focus must be on effective health promotion on the one hand, and on the other hand, on close coordination and multisectoral action in the health sector and beyond.

Background: Bipolar disorder, originally called manic depressive illness, is one of the most challenging psychiatric disorders to manage. Purpose: The objectives of this study are to research the socio-demographic and professional profile of patients hospitalized for bipolar disorder in the Dalal Xel mental health center of Fatick and to understand the factors associated with the evolution of the prevalence of bipolar disorder in the Senegalese context. Methods: It was a cross-sectional, retrospective, descriptive and analytical study. It was conducted in the hospitalization department of Dalal Xel Mental Health and included all patients hospitalized in this service between 2004 and 2013 and whose medical file was found. Results: The processing of the hospital service records made it possible to collect 6,896 patient files. Among these hospitalized patients, 731 were diagnosed with bipolar disorder (11.4%). The majority of patients were female (52.7%), lived in rural areas (53.4%), educated (66.2%). The majority had an occupation (74.1%) and were married (51.7%). The average age was 36.52 years with a standard deviation of 13.3 years. Between 2004 and 2013, the profile of the patient with bipolar disorder did not change for sex, age, professional activity, marriage. Religion and nationality remained influenced by the demographic context of Senegal. Conclusion: Bipolar disorder is influenced by biological (age, sex), social (married) and professional factors. The medical prescriptions must consider the patient's procreation and her professional activity. It is also important to involve the family in psychological support and to reinforce professional reintegration.