Background: Bipolar disorder, originally called manic depressive illness, is one of the most challenging psychiatric disorders to manage. Purpose: The objectives of this study are to research the socio-demographic and professional profile of patients hospitalized for bipolar disorder in the Dalal Xel mental health center of Fatick and to understand the factors associated with the evolution of the prevalence of bipolar disorder in the Senegalese context. Methods: It was a cross-sectional, retrospective, descriptive and analytical study. It was conducted in the hospitalization department of Dalal Xel Mental Health and included all patients hospitalized in this service between 2004 and 2013 and whose medical file was found. Results: The processing of the hospital service records made it possible to collect 6,896 patient files. Among these hospitalized patients, 731 were diagnosed with bipolar disorder (11.4%). The majority of patients were female (52.7%), lived in rural areas (53.4%), educated (66.2%). The majority had an occupation (74.1%) and were married (51.7%). The average age was 36.52 years with a standard deviation of 13.3 years. Between 2004 and 2013, the profile of the patient with bipolar disorder did not change for sex, age, professional activity, marriage. Religion and nationality remained influenced by the demographic context of Senegal. Conclusion: Bipolar disorder is influenced by biological (age, sex), social (married) and professional factors. The medical prescriptions must consider the patient's procreation and her professional activity. It is also important to involve the family in psychological support and to reinforce professional reintegration.