The aim of the present study was to evaluate the influence of the cuttings site and the age/state of the branch on the cuttings of the cola tree in the optics of its domestication (ex situ conservation). To this end, plageotropic and orthotropic branches having each one three nodes, equipped well were divided like cuttings and were placed in polyethylene bags containing a substrate based on a mixture of black cotton soil, chicken dejection and sawdusts broken up well. The results of this study indicate that 70 days after cuttings, on average 73% of the cuttings began again. However, after 90 days, the rate of survival recorded was 58.4%. Compared to the site of the cuttings, the best results were obtained with the cuttings taken on the orthotropic branches compared to the plageotropic branches. Compared to the state of the branch, the best results were obtained with the cuttings taken on the semi-ripened branches. Thus, the site of the cuttings and the age/state of the branch are parameters which condition the success of the cuttings of wild fruit trees such as the cola tree. It would be thus desirable that a study is carried out in order to evaluate the influence of the phyto-hormones on the cuttings of semi-ripened orthotropic branches.