Despite the strengthening of routine immunization, Niger continues to register measles outbreaks in some health districts. The objective of the study is to analyze the database of notifiable diseases (DND) for 2003-2015. A retrospective descriptive study was conducted. All suspected case of measles in the DND and the National Reference Laboratory (NRL) database were included. Data was analyzed using the software Epi Info version 3.5.3. A total of 173,997 suspected case of measles and 8,959 suspected cases of measles were recorded respectively for DND and the NRL database from 2003 to 2015. The age range of 1 to 4 years was the most represented with 36.78%. It was showed that 93.12% of the sample was not vaccinated or had unknown vaccination status. The sample having an adequate sampling state had represented 80.02% and 57.84% were positive for IgM. All regions recorded cases and deaths from 2003 to 2015 and there are many disparities across regions and years. The study revealed that there are many variations and disparities across regions and years.