Despite the gradual professionalization of the construction sector as well as the abundance of sand mining sites offered by the Western Cameroon Region, ignorance of materials by local builders persists. In the present work, the physical characterization of river sands of Santchou Sub-Division in Cameroon is performed. Experimental laboratory studies show that sand equivalents is greater than 80%; therefore, these materials are clean sands for concrete manufacture. The Materials from Ntingue and Fombap are well-graded. As for materials from Faungwa are poorly graded. The fineness modulus of Fombap materials indicates that they can be used as sand for concrete mnufacture, provided to use Portland cement. Materials from Ntingue and Faungwa are of very high fineness modulus; therefore, particle size distribution requires correction before their use in formulating concrete. For such a correction, it is proposed their association with Fombap sand in suitably chosen proportions using tables obtained in this work. The formulation should be carried out using one of the modern methods. Compression tests on concrete samples made up with these proposals provide good resistance, which demonstrates their validity.