The access to safe water remains a serious major concern in Africa particularly in rural areas. The aim of this study was to assess the efficiency of pond water treatment consumed by plateau de Batéké population in Bita village using Moringa oleifera seed powder and Vetivera zizanoides root powder. Pond water samples were treated with different concentrations of M. oleifera seeds and V. zizanoides roots as a bio-coagulant. The measurement of physico-chemical parameters in the course of time has permitted to determine the optimum conditions and to evaluate the treatment efficacy. Results revealed that Moringa oleifera seeds are more efficient than Vetivera zizanoides roots. This activity is dose dependent. After one day post-treatment, the rate of turbidity reduction is 93.53% at the concentration of 1.818 g/l. Also, the treatments allowed the reduction of nitrates and nitrites in treated pond water. These results indicate that M. oleifera improve considerably physic-chemical quality of treated pond water. Thus, this approach is ecological and respectful of the environment. It is inexpensive, simple and beneficial for the populations of the rural zones. Moreover, M. oleifera is a plant species particularly easy to cultivate in an intensive way and is adapted to the tropical climate of Africa.