As part of the search for natural substances of plant origin as an alternative to chemical pesticides in agriculture, Terminalia ivorensis, to which antifungal virtues are lent, was used in this study to evaluate in vitro the sensitivity of Fusarium oxysporum. The antifungal activity was evaluated by the double dilution method on PDA medium with aqueous and ethanolic extracts at 70% leaf and bark of Terminalia ivorensis compared to Mancozan 80 WP which is a widely used reference fungicide. According to the results, only 70% ethanolic extracts have fungicidal properties on Fusarium oxysporum. The ethanolic bark extract of Terminalia ivorensis was fungicidal at CMF = 6.25 mg / mL. For ethanolic leaf extracts, the CMF was 12.50 mg / mL. The phytochemical sorting of the various extracts showed the presence of secondary metabolites which could justify the antifungal activity of Terminalia ivorensis and its use in traditional medicine.

In Ivory Coast, the barks of Enantia polycarpa and the leaves of Bersama abissynica, two medicinal species are usually used by populations to treat various diseases such as malaria, diarrheas and cutaneous diseases. To estimate the biological dangers connected to the frequent use of these medicinal plants, the current study was undertaken with objective to evaluate the cytotoxic activity of 70% ethanolic extract on Human Foreskin Fibroblast (HFF) cells in the in vitro culture. 70% ethanolic extract of plants were prepared and the colorimetric test of the MTT is used to evaluate the toxicity of these extracts. The results proved that the ethanolic extract of Enantia polycarpa showed the biggest yield (56,4%). The 70 % éthanlic extract of Bersama abissynica is not cytotoxic at 1000 µg / ml concentration, but mitogen. Our study has shown that the ethanolic extract of Bersama abissynica stimulates HFF cells in division growth (268%). While Enantia polycarpa seems cytotoxic on HFF cells at 1000 µg / ml concentration (36% of viability confluents cells and 55% of viability cells in division). Such results well support that the moderate use of these medicinal plants only represents a limited risk in terms of toxicity. However, follow-up studies must be envisaged in order to determine the chemical compounds responsible of the cytotoxic effect at Enantia polycarpa and those responsible for the mitogen effect at Bersama abissynica.