A total of 324, 21-days old cobb 500 strain chicks were used to evaluate the effect of graded level of wheat bran supplemented with natron on the growth performances of broiler chickens at finisher phase. Three groups of chickens subjected to a basal diet with respectively 0, 15 and 30% of maize replaced by wheat bran (R0, R15 and R30) were compared to six others groups fed on basal diets supplemented with 0.2 or 0.4% natron. The mains results revealed no significant effect of different treatments on feed intake. However, all other growth parameters including weight gain and feed efficiency decreased with increasing level of wheat bran and natron in the rations. In the same trend, carcass yield and the abdominal fat tend to decrease with increasing level of wheat bran in the diet. In contrast, the relative weight of gizzard, and weight and density of intestine tends to increase with increasing level of wheat bran. In conclusion, it is not economically profitable for productive performances to use natron as feed additive to improve wheat bran valorization in poultry production.