A number of plants and their part are used as chewing sticks in Kano, Nigeria. Different researches have been carried out on the antimicrobial effect of chewing sticks on oral micro organisms. This research work was aimed to determine the antibacterial activity of aqueous and ethanolic extract of plants and five different types of conventional toothpaste, commonly used in Kano on clinical isolate of staphylococcus and streptococcus species obtained from dental problem with a view to find the most efficacious one among them, sensitivity disc method was used to test the antibacterial activity of chewing sticks, A. lebbeck, J. curcas, A. Indica, N. latifolia and V. amydalina were the plants and Toothpaste are Dabur, Florish, Close up, Maclean and Mymy. It was found that none of the plants 'aqueous extract had activity on the two species of the bacterial isolate at various concentrations. But in ethanolic extract were active against all the test bacterial isolate obtained from dental problem with greater zone of inhibition in N. latifolia, followed by A. Indica and smaller zone of inhibition in J. curcas. In comparism with conventional toothpaste, chewing sticks produced similar or greater zone of inhibition than Mymy (toothpaste). Some of the secondary metabolites were all presents with high content in ethanolic extract. The extracts of these plants and toothpastes may serve as sources for chemotherapeutic agents of the management of orofacial infection.