Taï National Park (TNP) is home to an exceptional wealth of wildlife, with 146 species of mammals, representing 93% of the species found in the western Guinean forest zone. Due to this remarkable biological diversity, numerous conservation and scientific research programs have been implemented there with a view to ensuring the park’s sustainable management. However, despite the multitude of studies carried out, knowledge of the ecology of small and medium-sized carnivores remains patchy, mainly due to their discreet lifestyle and predominantly nocturnal activities. The aim of this study was to analyze the influence of certain environmental and anthropogenic factors on the spatial distribution of small and medium-sized carnivores in Taï National Park. To this end, 285 camera traps were deployed throughout the park between March 2019 and February 2020. The results indicate that the distribution of the marsh mongoose and Johnston’s genet is positively influenced by distance from research or ecotourism areas, which have high concentrations of these two species. In contrast, the distribution of the brown mongoose, the Liberian mongoose, and the African civet shows no significant relationship with the preselected environmental and anthropogenic variables, suggesting a relatively homogeneous distribution within the park. These results provide useful additional information for managers of Taï National Park and constitute an important scientific basis for improving conservation strategies for small and medium-sized carnivores.