This study is a contribution to fonio’s agroecological intensification cultivation. Objective is to propose innovative recommendation based on interaction between fertilization*seed rate *sowing arrangement to increase fonio yields. A factorial trial was set up in Mali. Paddy yield and plant density were evaluated. Treatment involving mineral fertilization was the most productive with 10% gain over those involving compost and 30% over those involving zero fertilizer. In zero fertilizer condition, the best treatment with 640 kg ha-1 yield paddy combine zero fertilization, 15 and 30 kg ha-1 seed rate and broadcast sowing. In mineral fertilization condition the best treatment with 1090 kg ha-1 combine mineral fertilizer, 15 and 30 kg ha-1 seed rate and broadcast sowing. In compost condition, the best treatment combine compost, 15 and 30 kg ha -1 of seed rate and broadcast sowing and compost, 1 and 2 kg ha -1 seed rate and line sowing, with an average paddy yield of 835 kg ha-1. Doubling seed rate does not affect paddy yield, but affects essentially plant density for treatments involving broadcast sowing. Treatments involving broadcast sowing with 30 kg ha-1 of seed rate have plant density higher than 46%, 71% and 88% then treatments including broadcast sowing, 15 kg ha-1 seed rate, line sowing and hill dropping sowing at a seed rate of 2 kg ha-1, respectively.