A survey was conducted by administering a questionnaire to identify common bean (Phaseolus vulgaris L.) conservation methods used by farmers in the Hauts-Plateaux division, west region of Cameroon. To reduce post-harvest losses of common bean (P. vulgaris) in the study area, a six-month study was carried out on red and black beans. Vegetable powder of tobacco leaves (Nicotiana tabacum) was produced and tested against the bean weevil (Acanthoscelides obtectus). Tobacco leaves were dried to 13.5% moisture content, crushed and sieved to obtain a powder at pH 5.63. This powder and two other synthetic insecticidal powders (Antouka and Protect DP) based on permethrin were incorporated at a dose of 1 g kg-1 in batches of beans. The coated seeds were placed in 125 mL polyethylene boxes containing 100 seeds each, then stored for 6 months in a room at a temperature between 15 and 27 °C. The experimental set-up applied for each variety was a complete randomized design comprising four treatments and four replicates (Control without any treatment, Tobacco, Protect DP, Antouka). Data on perforated seeds, weevil emergence and mortality were observed throughout the experiment. Results showed that 41% of farmers use synthetic insecticides, 36% do not use any substance, 14% wood ash, 9% fir leaves. This study showed that tobacco powder significantly reduced the puncture of beans by weevils, indicating the importance of alternatives means for pest management. It also emerged from this study that the black bean is more resistant to weevils than the red one.