Background: The covid-19 has reached DRC. Numbers of confirmed cases and deaths are increasing despite the confinement strategy implemented since March 2020. In addition, mainly for economic reasons, the population is claiming for the confinement measures to be waived, which may lead to an increase of the risk of infection, morbidity and mortality related to Covid-19, which calls for a more focused prevention strategy. Nevertheless, Covid-19 prevention approach is more social distancing and hygiene oriented, with few attention to nutrition and other lifestyle aspects such as alcohol use, smoking and physical activity.Objective: to support the DRC health authority’s efforts for empowering populations for better prevention, by designing a more comprehensive approach including nutrition and other lifestyle factors.Design: This paper is a context analysis and a review and viewpoints about different health aspects that should be integrated when designing a national comprehensive strategy to prevent covid-19 in DRC.Conclusion and recommendations: The public health authorities to empower the populations against Covid-19 infection through a comprehensive approach consisting of sensitization at all levels, not only about social distancing and washing hands as it’s being the case, but also and of utmost importance, about nutrition and other lifestyle factors such as alcohol use, smoking and physical activity since they affect immunity. The nutrition factor should include the dietetic management of patients with chronic diseases and/or co-infections. Therefore, task forces for fighting covid-19epidemic in DRC should include nutrition specialists and researchers for more comprehensive approaches against covid-19, to the ultimate interest of the population.