Diffuse splenic small cell red pulp lymphoma (SDRPL) is a rare type of indolent non-Hodgkin’s lymphoma composed of small B cells that involve the red pulp of the spleen, bone marrow, and peripheral blood. It was included in the 2016 revised WHO classification as splenic B-cell lymphoma/leukemia, unclassifiable.
We report through this observation the case of a patient in whom the SDRPL was revealed by an autoimmune hemolytic anemia, and whose study of the blood smear made it possible to suspect an initial diagnosis, consolidated secondarily by the results of immunophenotyping.
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