The study investigates environmental impact of indiscriminate waste disposal on river channel in part of Akoko-Region, Ondo State, Nigeria. The study further identified; method of waste disposal within the study area, influence of waste disposal method on open space and streams, reaction of water to waste disposal method, environmental problems associated with waste deposited on river channel. Primary data for the study were generated through questionnaire administration and water sample analysis. Sixty questionnaires were systematically distributed in each of the selected sampled locations that included Ise, Akunu, Ikakumo, Ugbe and Ikare settlements based on interval of fourth house from another house. Twenty-two water samples were randomly collected from the selected sampled settlement in order to identify their physical properties using in-situ method. Simple percentages were employed for data analysis while tables and figures presented findings of study. It was observed that wastes are being flushed into streams and thereby affects the odor, taste and coloration of water quality. Flooding activities identified in this area is majorly caused by indiscriminate waste disposal that blocks water drainages. The study therefore recommends provision of waste management strategy that will ensure neatness of environment and avoid pollution of water with effective refuse collection and disposal system within the study area and the related environments.