Volume 57, Issue 1, October 2021, Pages 30–35
Salifou Karimoune Fadjimata1, Adamou Hassane Hassane2, Amadou Tidjani Ilagoouma3, and Karimoun Massalatchi Illiyassou4
1 Department of Chemistry, Faculty of Sciences and technics, Materials, water and environment Laboratory (MWEL), Abdou Moumouni University. BP 10662, Niamey, Niger
2 Department of Chemistry, Faculty of Sciences and technics, Materials, water and environment Laboratory (MWEL), Abdou Moumouni University. BP 10662, Niamey, Niger
3 Department of Chemistry, Faculty of Sciences and technics, Materials, water and environment Laboratory (MWEL), Abdou Moumouni University. BP 10662, Niamey, Niger
4 Department of Chemistry, Faculty of Sciences and technics, Materials, water and environment Laboratory (MWEL), Abdou Moumouni University. BP 10662, Niamey, Niger
Original language: English
Copyright © 2021 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The aim of this research is to control the quality of Ciprofloxacin used alongside and in the health centers and sold in Niamey city by using Thin Layer Chromatography method to compare the results achieved in order to contribute to informed decision-making for possible interventions. This research aimed to investigate on eleven samples distributed as follows which five samples are from pharmacies, five samples are from street vendors and one sample specialty used as reference to check the quality control of them. The different reagents used are: Methanol, Dichloromethane, Ammonia at 260gL-1 or Pure ammonia, Acetonitrile and 0.1 M NaOH. The migration of all the samples in proposed diluent shows that all of them contain the active ingredient of ciprofloxacin. The percentage of the active ingredient were calculated as per protocol of Clarke’s analysis of drugs and poisons in chemistry guidelines. It varies from 90.90 to 109.09 for pharmacies and 98.18 to 106.35 for the street vendors.According to the results of the different frontal reports, each sample contains the percentage of active principle recommended by WHO which is 90 to 110 % of active ingredient recommended by WHO.This technique of quality control can be used for practical work or tutorial and laboratories where drug quality control mechanism is not often checked.
Author Keywords: Ciprofloxacin, Thin Layer Chromatography, pharmacies, street vendors, Niamey.
Salifou Karimoune Fadjimata1, Adamou Hassane Hassane2, Amadou Tidjani Ilagoouma3, and Karimoun Massalatchi Illiyassou4
1 Department of Chemistry, Faculty of Sciences and technics, Materials, water and environment Laboratory (MWEL), Abdou Moumouni University. BP 10662, Niamey, Niger
2 Department of Chemistry, Faculty of Sciences and technics, Materials, water and environment Laboratory (MWEL), Abdou Moumouni University. BP 10662, Niamey, Niger
3 Department of Chemistry, Faculty of Sciences and technics, Materials, water and environment Laboratory (MWEL), Abdou Moumouni University. BP 10662, Niamey, Niger
4 Department of Chemistry, Faculty of Sciences and technics, Materials, water and environment Laboratory (MWEL), Abdou Moumouni University. BP 10662, Niamey, Niger
Original language: English
Copyright © 2021 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The aim of this research is to control the quality of Ciprofloxacin used alongside and in the health centers and sold in Niamey city by using Thin Layer Chromatography method to compare the results achieved in order to contribute to informed decision-making for possible interventions. This research aimed to investigate on eleven samples distributed as follows which five samples are from pharmacies, five samples are from street vendors and one sample specialty used as reference to check the quality control of them. The different reagents used are: Methanol, Dichloromethane, Ammonia at 260gL-1 or Pure ammonia, Acetonitrile and 0.1 M NaOH. The migration of all the samples in proposed diluent shows that all of them contain the active ingredient of ciprofloxacin. The percentage of the active ingredient were calculated as per protocol of Clarke’s analysis of drugs and poisons in chemistry guidelines. It varies from 90.90 to 109.09 for pharmacies and 98.18 to 106.35 for the street vendors.According to the results of the different frontal reports, each sample contains the percentage of active principle recommended by WHO which is 90 to 110 % of active ingredient recommended by WHO.This technique of quality control can be used for practical work or tutorial and laboratories where drug quality control mechanism is not often checked.
Author Keywords: Ciprofloxacin, Thin Layer Chromatography, pharmacies, street vendors, Niamey.
How to Cite this Article
Salifou Karimoune Fadjimata, Adamou Hassane Hassane, Amadou Tidjani Ilagoouma, and Karimoun Massalatchi Illiyassou, “Comparative study of the quality control of Ciprofloxacin sold in Niamey city by Thin Layer Chromatography,” International Journal of Innovation and Scientific Research, vol. 57, no. 1, pp. 30–35, October 2021.
