Medical treatment of ectopic pregnancy (EP) is based on the administration of methotrexate (MTX). It concerns ectopic pregnancy with β-hCG <10000 without cardiac activity and applies to women informed, without history of ectopic pregnancy and who understand the predictive signs of break. These women should always be monitored until β-hCG negativity. The risk of tubal break persists throughout the treatment with MTX. The authors report three cases of ectopic pregnancy treated medically and whose evolution has been marked by a break. They talk through these cases about the indications and limitations of medical treatment and the risks of tubal break under medical treatment.
Trastuzumab is the first target molecule designed for breast cancer treatment. In first-line metastatic, trastuzumab in combination with chemotherapy significantly improved survival of patients bearing HER2-positive breast cancer. In adjuvant trastuzumab was tested in several randomized trials. In contemporary literature, many strong arguments confirm the clear survival benefit of trastuzumab in adjuvant administered concomitantly with taxane-based chemotherapy and concomitant with radiation therapy, and for a period of one year.
Carcinosarcomas are rare uterine cancers and carry poor prognosis. Although these tumours usually arise de novo, some cases developed under tamoxifen therapy have been reported. We report a case of uterine carcinosarcoma occurring in a postmenopausal patient benefiting from tamoxifen therapy as adjuvant treatment of breast cancer.
A case of a malignant mesothelioma of clitoral location is reported in a 52 year-old woman.The microscopic and immunohistochemical exam of biopsy conﬁrmed the diagnosis of malignant mesothelioma of the clitoris. The computed tomography scan of thoraco abdominal pelvic was normal. The patient underwent surgical treatment followed by radiotherapy and chemotherapy. Most malignant mesotheliomas are pleural location; they rarely occur within the peritoneum and their clitoral location is exceptional. Our objective about this particular case is to discuss the diagnostic problems of exceptional tumour of the clitoris and clinical and pathologic aspects.