The present study is part of the Home Garden project and Domestication in the Sudano-Sahelian region of Cameroon. The aim of the work is to contribute to the promotion of Moringa oleifera Lam. for its better valorization in Cameroon. An ethnobotanical survey was conducted among 158 stakeholders of Moringaceae in 15 communities in the Sudano-Sahelian zone through the Rapid Participatory Reseach Method (RPRM). The questionnaire is based on the knowledge, practices and indigenous knowledge of the people on M. oleifera. It appears that the leaves and seeds are the most commercialize in the region. The leaves, roots and seeds are the parts used in traditional medicine. Famer’s of the Sudano-Sahelian area of Cameroon treat 19 diseases with the different parts of the plant. Six diseases (dental caries, HIV / AIDS and malnutrition, diabetes, high blood pressure, sore eyes and typhoid) are commonly treated in the study area. The plant would be introduced in the Sudano-Sahelian zone of Cameroon by the Fulani to 17siècle. The Guiziga, Mafa, the Moufou and Toupouri use six criteria based leaves, pods, seeds and trunk to distinguish each trees of M. oleifera. These qualitative criteria can be used baseline data for the morphological characterization of the species. These results can be used as database for the selection of ecotypes solicited by populations.