Gestational trophoblastic disease (GTD) is a complex pathologic entity requiring adequate management and surveillance to prevent and diagnose patients with gestational trophoblastic neoplasia (GTN) early. causing a major myometrial invasion leading in rare cases to uterine rupture, reporting in this article a case of uterine rupture on GTN, this is one of the rare case published, we present the case of 25-year-old patient, followed for GTD moving to GTN, chemotherapy was started according to the FIGO score which classified her at low risk, she consulted in a state of shock, the diagnosis of hemoperitoneum was made, emergency laparotomy revealed uterine rupture requiring haemostatic hysterectomy.