The study examined housing condition and environment induced ill-health with a view to identify ways to improve standard living in Akoko region, Ondo state, Nigeria. The specific objectives of the study examined; the household population and occurrence of ill-health and inter-relationship of ill-health and housing condition within the study area. Questionnaire administration harvested information on physical housing variables, available facilities, infrastructural services, housing conditions, and health status of respondents in Ikare, Ajowa and Ose that represent large, medium, and small towns respectively. Simple percentages and correlation analysis were used to summarize data, while tables, charts and figures presented results of the findings. The study revealed that diverse ill-health abound in the study area. However, body pains and malaria have the highest proportion of 18.4% and 23.7% respectively as a result of the observed inter-relationship between body pains and increased malaria parasites. The high occurrence of sleeplessness in the study area is related to the kind of noise being exposed to in this area where socio-economic activities (such as multipurpose, religious, extreme labour activities) are regularly taken place. The study therefore recommends that accessibility to quality housing should be prioritized by the people with standard housing conditions that could facilitate sustainable healthy living.