The beat hunting represents an important source for food and income for populations in the northern Benin. But, although the bush meat is well appreciated by the population, it could also be a source for diseases then the wildlife is a great reserve of several dangerous microorganisms. In that respect the appearance of Ebola and Lassa virus in Benin had affected the consumption of bush meat and thereby the beat hunting. The analysis of this economic activity in the context of the Lassa epidemic was the subject of the present study. Based on a random sample of 150 hunters and using the “Before-and-After” approach, the results showed that the averages of gross margins in the absence and in the presence of the epidemic were 126 314 F and 140 489 F CFA respectively. With a probability of p=0.20, the difference of means is however no significant, suggesting, as also showed by the score of the hunters’ perception on the impact of the epidemic, that the Lassa epidemic had only a limited financial effect on their hunting activity; hoping thereby that their activity again increases as soon as the psychosis generated by Ebola and Lassa virus would disappeared. The indifference of hunters to the risks linked to these epidemics calls however, for the need of deeper future studies on the perception and motivation of hunters for hunting in periods of sanitary crisis in order to prevent public health catastrophes in the study area.