This study investigated the relationship between Personal Resources, Work –Life Balance and Job Satisfaction on Manifestation of Workplace Stress in a Sample of Women Bankers working in First Bank Plc in Oyo State. In each of the 33 Local Government Areas in Oyo state, there is at least one First Bank, thus the respondents of this study spread over these LGAS. Descprtive research design was used in this study. A purposive sampling technique was used to select the 182 women bankers that constitute the respondent of this study. Four null hypotheses which were formulated and tested at 0.05 level of significant guided the study. Four instruments were used to elicit information from the respondents. They are:- Occupational Stress Index (OSI), Job Satisfaction Scale, (JSS), Work - Life Balance Scale and Personal Resources questionnaire. Descriptive statistics comprising of frequencies and percentiles of categorical data have been used to describe the profile of the respondents. In order to calculate the reliability of study variables, scores of Cronbach’s alpha coefficient was utilized. A simple and hierarchical regression was employed to test the hypotheses. Pearson correlation has also been used. The relationship between twelve dimensions of occupational stress index (OSI) and the satisfaction with life, work-life balance, job performance, and job satisfaction have been determined following Pearson correlation the relationships are negatively correlated and statistically significant at p<0.05. Six dimensions of occupational stress have negative correlations with satisfaction with life scale. Nine dimensions of occupational stress index dimensions are negatively correlated with work-life balance. Suggestions and recommendations were made that women bankers should find time to participate in recreational activities (e.g. music, sports), management and utilization of free times and weekends, regular exercise, and moderate food and drinks (avoiding excessive consumption of coffee, tea or ciggarettes).