A survey has been conducted on the impact of wastes produced in the great establishments of Irhambi-Katana grouping, territory of Kabare, East of the Democratic Republic of the Congo. This study aimed to identify the impact of wastes produced by the great establishments of Irhambi-Katana grouping on human, the surrounding population and the environment. For reaching this objective, we used the method of collection of data by a questionnaire of inquiry and an interview in the great establishments of our study medium. After this inquiry and the analysis of the data collected, we accepted that the wastes in the great establishments of Irhambi-Katana grouping are bad stored according to the results found from our inquiries, the bad storage of the wastes in the great institutions of the Irhambi-Katana grouping sweeps along diseases and the nature pollution (atmospheric, of the water and of the soil) and the sensitization by an environmentalist agent and the creation of dump for wastes are the means for fighting against the consequences of these lasts on the environment and the human health. Thus, we recommended to the government to command respect the law on the wastes management and to the great establishments of Irhambi-Katana grouping to evacuate the wastes that they produce far from themselves for safeguarding the environment, the human and the surrounding population.