Wetlands and their biodiversity species have been undergoing an alarming degradation in the past recent years. The overall objective has been to determinate the various invasive plant species found in the study area. Floristic inventories based on the development of transects and quadrats helped to make surveys by using coefficients of abundance-dominance and sociability. Physico-chemical parameters of the Nyong river were measured. Species richness of study sites amounts to 20 species distributed in 17 families. Results shown that the distribution of macrophytes varies with Shannon diversity index, from 3.193695 (Ekombitie/Mbega) to 1.263136 (CDE/CAMWATER). Echinochloa pyramidalis (51 %) is the most abundant specie in the study sites. The result shown the causes and factors limiting the potential of the biotope of the Nyong River. It has been clearly shown that invasive plants contribute in a significant way to euthrophication of the river: Echinocloa pyramidalis, 51%; Ipomea aquatic, 18.31%; Nymphaea lotus,12.83%; Leersia hexandra, 9.15%; Commelina benghalensis, 9.15%. The ecosystem approach for the better management of this site is proposed. From this study we therefore open another parenthesis for research which is based on managing wastes within the Mbalmayo council area and monitoring the quantity and quality of the waste stream leaving Yaounde and other environs into the Nyong River. This will help to reduce the pollution of this river, monitor point source and non-point source pollution sources and hence to reduce the proliferation of macrophytes since one of the best options of ecosystem restoration is preventing nutrient loading.