Tea extracts are used in many over-the-counter preparations claiming to promote weight loss. The rationale for this usage includes reports that khaya extract inhibit the digestion/absorption of carbohydrate and fat into gastrointestinals tube of rats. The investigators in this study tested the potential of increasing doses of three extracts concentrations (3.3mg/Kg of khaya tea, 6.6mg/Kg of khaya tea, and 9.9mg/Kg of khaya tea) to induce weight loss, steatorrhea, and blood lipid alterations in rats ingesting a high-fat diet. During the 90 days on the HFD, the animals were treated with 3.3mg/Kg, 6.6mg/Kg and 9.9mg/Kg of body weight of khaya tea. The time course of the body weight and obesity-related biochemical parameters were evaluated. The animals were fed with a standard diet (SD, n= 6) or high-fat diet (HFD, n= 6) for 90 days. After 90 days of treatment with 3.3mg/Kg, 6.6mg/Kg and 9.9mg/Kg of body weight, Khaya tea suppressed the increases average 37.43% of the changes in body weight gain (expressed as % of initial body weight) (P< 0.05) and decreased the serum triglycerides and low-density lipoprotein (LDL)-cholesterol concentrations at both doses (from 69±2 to 50.3 ±2.7 mg/dL, from 27±1 to 23.5 ±1 mg/dL; P< 0.05, respectively) after they had been increased by the HFD. The abdominal lipids content was also decreased by the diet containing khaya tea (from 7.30 ±0.11 to 5.52 ±0.16 mg/dL; P< 0.05). These results suggest that khaya tea could be a potentially therapeutic alternative in the prevention of obesity caused by a HFD.