This study investigated the susceptibility pattern of coliform bacteria isolated from sachet and borehole waters sold in Abakaliki metropolis. This was done by determining the presence of Escherichia coli, Klebsiella spp and Enterobacter spp and their antibiotic susceptibility profile using commercially prepared antibiotic discs. A total of Five hundred (500) samples of water comprising 250 each from selected brands of sachet water and boreholes were obtained from water dispensers in Abakaliki metropolis, Ebonyi State, Nigeria. Results of biochemical analysis revealed that out of the 311 confirmed isolates, 138 (55.2%) were from sachet waters while 173 (69%) were from borehole waters. The susceptibility profile of the isolates to ten antimicrobial agents indicated that majority of the isolates showed little susceptibility and was highly resistant to the following antimicrobial agents (nitrofurantoin, amoxycillin, ampicillin, ciprofloxacin, tetracycline, norbactin/norfloxacin, ofloxacin, cefuroxime and gentamicin). This showed that they exhibit multi-drug resistance pattern which is a common feature of medically important coliform bacteria. None of the water sources met the WHO microbiological standards for drinking water and thus pose a serious health risk to its consumers and users if not properly treated. We therefore report the presence of multi-drug resistant coliform bacteria in sachet and borehole waters sold in Abakaliki metropolis, Ebonyi State, Nigeria.