The Greeks were the main cocoa traders in South-Cameroon during the colonial period. They arrived in small groups to be employed as prospectors, then commercial agents on behalf of the major treaty trade companies as the Paterson Zochonis (PZ), the Company of Haut Ogooué (SHO), the French West Africa company, R.W. King or John Holt, the small colony of Greek commercial agents of Cameroon has embarked on building a commercial destiny which the main beam remained the marketing of annuity products including cocoa. This article examines the role of the Greeks in the development of trade in agricultural products for export in Cameroon and more specifically in the chocolate products rich region of Nyong and Sanaga, located in the centre of the territory of Cameroon. The Greeks have, thanks to their proximity to the major colonial corporations, taken the measure of the opportunities offered by the market of the agricultural products for export in colonial Cameroon and more specifically in Yaoundé, administrative capital and main town of the region of Nyong and Sanaga. Then, they launched their commercial assault in the surrounding communities of: Sa' a, Akonolinga, Mbalmayo, Obala, etc. Among the most active traders, there were for example, Kritikos, Mikes, Demetropoulos, Gaetanos, Trianfilides, Pollakis, Papadopoulos and Mavrommatis. Thus, in less than half a century, Greek traders have, from the cocoa trade, transformed many bush markets in the region in real centres of trade in the territory.