Sesame (Sesamum indicum.L) is one of the most important oilseed crops, having seeds and oil that are highly valued as a traditional health food and recently, natural antioxidants have gained increased interest because natural food ingredients are safer than synthetic ones. Antioxidant activity and bioactive molecular tests were carried out on 16cultivars of sesame seeds from different areas in the world. This activity was found to be high ranging between 59 and 64% for the samples; this result can be related to the large amount of phenolic and flavonoid contents with the values 3.79-3.97 mg/g and 0.127-0.147mg/g respectively. The flavonols content was ranging between 0.400 and 0.421mg/g EQ per mg extract. those results strongly suggest that phenolics compounds are a good natural antioxidant and also put the American cultivar in the first choice for the customer with the Indian and Morocco ones. Due to its all favorable properties; sesame seeds could be used in either food or cosmetic and pharmaceutical products.
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