The care-associated infections (CAI) are a public health problem. WHO showed that 8.7 % of hospital were affected by CAI. In Morocco in 1994, the prevalence of CAI was 10% in regional hospitals. The surgical site infections (SSI) are the most common complication of surgery. This is due to several factors related to the person, staff, the environment and the organization of care. The study aims to determine the prevalence and factors of Surgical Site Infections at the Regional Hospital of Meknes. This is a descriptive cross-sectional study conducted by a team previously formed using a plug which is filled in front of 111 patients ; and a questionnaire administered to 20 nurses of surgery service. The prevalence of SSI is 16 %. Diabetics are exposed to five times more likely to develop an SSI. Age is not a risk factor even the slice of more than 50 years accounted for 33 % of SSI cases. Over three years, less than 50 % of staff trained in hospital hygiene.