Trade liberalization is one of the greatest challenges facing environmental sustainability in Uganda. However, this seems to be far from reality because there are indications that trade liberalization as in a number of aspects failed to achieve the desired outcome as there are negative impacts on developing countries. The study was carried out to determine how trade liberalization and environment relate and how they can be mutually supportive with the aim to enhance the existing knowledge and even widen the understanding while developing trade policies to undertake appropriate measures that can enhance environmental sustainability. The researchers employed quantitative method of data collection. The secondary data was obtained through extensive literature review of documents. The results of the study show the need to lobby for more environmental friendly technologies, holding actors and stakeholders responsible for their dubious actions and promote incentives for proper hazardous waste management. The report underlines that to balance the trade policies; environmental standards will require a coordinated public private partnership and multilateral cooperation.