Afield experiment was conducted to study the effect of integrated use of organic and inorganic fertilizers on some quality parameters of two maize cultivars in arid land in west Saudi Arabia during two seasons 2012/2013 and 2013/2014. The experiment was laid out in split split plot arranged in a randomized complete block design with three replications. The experiment consisted of two maize cultivars, three levels of chemical fertilizers NPK (20:20:20) applied at 100, 500 and 1000kg/ha and eight treatments of alfalfa green manure, chicken manure, cow manure and their combinations. The quality parameters studied were protein, oil and minerals content. The results indicated that protein content of maize grains was increased significantly with the increasing of chemical fertilizer for the two seasons, whereas the application of organic fertilizers increased the protein content significantly only in the second season. All measured quality parameters under organic treatments were recorded the highest and significant values in the second season. Among the organics, the combination of alfalfa, chicken and cow manures was superior to other treatments in term of protein content and minerals, where the highest protein content recorded in the second season was 11.14% comparing to the lowest value recorded by the control which was 9.63%, the mineral content in the second season for the same treatment for potassium, calcium, iron and zinc was 17.99, 2.09, 0.69 and 0.18 g/kg whereas for the control was 16.65, 1.29, 0.473 and 0.074 g/kg for K, Ca, Fe and Zn respectively. The oil content was affected by organic manures only in the second season. Alfalfa green manure recorded the highest oil content in the second season with a percentage of 5.6% whereas the lowest content was recorded by the control which was 5.11%.