Assessment of the relationship between quality of care provided to people living with HIV/AIDS (PLWHA) and socio-economic variables was undertaken in Morogoro Municipality whereby a cross-sectional survey approach was adopted. Ninety PLWHA from two NGOs that are well known to support PLWHA in Morogoro Municipality were involved. Data were collected through face to face interviews. Descriptive and inferential methods of data analysis were used. Six variables were tested to determine their relationship with the quality of care in three components of care. Results showed that counseling and testing was significantly influenced by only the duration of living with the virus while medical care was affected by age and education level of respondents. The communication and behaviour change component was affected by respondents' age and marital status. It is therefore recommended that education be strengthened to PLWHA and even the care providers that high quality of care is essential to all PLWHA regardless of their socio-economic backgrounds so as to improve the quality of and prolong their lives.