This study was carried out with the aim of evaluating the impact of the contributions of organic fertilizers (Tithonia diversifolia, Batguano) on the growth and yield of maize cultivation in monoculture and in association with cowpea. From this study, the following results were recorded: In monoculture, Bat-guano gives a yield of 4.18 T/Ha significantly higher than Tithonia diversifolia with 3.73 T/Ha in the QPM3 variety; 3.82 T/Ha against 2.43 T/Ha with the Mus1 variety. In maize-cowpea association, Bat-guano gives the yield of 3.19 T/Ha significantly higher than Tithonia diversifolia with 2.77T/Ha in the QPM3 variety, 2.89 T/Ha against 1.40 T/Ha with the variety Mus1. The study that was conducted highlights a clearly beneficial effect of the use of natural fertilizers, namely Tithonia and bat guano, on the cultivation of maize in monoculture as well as in association with cowpea. Data analysis indicates that the treatment with bat-guano was found to be the manure capable of significantly improving the vegetative and yield components of grain maize compared to tithonia. In general, both treatments had higher yields compared to the control (F0).