The G5 Sahel, a region marked by its rich history and vast potential, confronts a myriad of socio-economic challenges and opportunities. This article delves into the intricate economic landscapes of the G5 nations, highlighting the pivotal role of resource-driven conflicts, with a focus on the significance of uranium in Niger’s affairs. As the region grapples with external economic dynamics, the enduring economic influence of colonial powers, notably France, is evident. The burgeoning economic engagements of China in the Sahel further complicate the geopolitical canvas. However, the region’s resilience shines through indigenous solutions, emphasizing the importance of traditional economic systems. Examples such as Mali’s ‘Tontines’ and women-led cooperatives in Niger underscore the potential of grassroots initiatives in fostering stability. Furthermore, the prospects of regional economic collaboration among the G5 Sahel nations present a pathway to harnessing collective growth and reducing tensions. The article advocates for a balanced approach: leveraging external partnerships while prioritizing local solutions and regional collaborations, as the G5 Sahel charts its course towards a sustainable future.