In Ivory Coast, the decade of politico-military crisis has led to the degradation of national parks, After this crisis, knowledge of the wildlife diversity of these forests is needed to propose appropriate conservation measures. For this purpose, this study was conducted in the Mount Péko National Park (MPNP), located in western Ivory Coast. It aims to inventory the means and large mammals, to establish their spatial distributions and to determine their conservation status as well as the threats of human activities that weigh on them. The methodology used consisted first of all in surveys with the managers of the park and the local populations in order to have data on the fauna of the region. Pedestrian surveys inside the park were organized. At the end of this study, ten (10) species belonging to four (4) orders and six (6) species from (2) orders respectively of large and medium mammals were confirmed from direct and indirect observations. Most of these species occur in the surveyed areas except Cercopithecus campbelli, Civettictis civetta, Procavia capensis found only in the north and Syncerus caffer nanus observed only south of the park. Among the large mammal species, in addition to Loxodonta africana (VU), Pan troglodytes verus (EN) and Cephalophus sylvicultor (NT), all other species are listed in the category of Least Concerned (LC), according to IUCN. Similarly, apart from Phataginus tricuspis classified as Vulnerable (VU), all species of mammalian means are included in the LC category. However, the sustainable conservation of these mammals is threatened by various anthropogenic activities within the MPNP. In order to safeguard the biodiversity of the park, it is necessary to implement the management and management plan of the park, to involve all the stakeholders in the actions of monitoring, communication for a change of behavior and in real management MPNP. Scientific studies and ecological monitoring activities will need to be carried out to collect more comprehensive data as a tool to guide the sustainable management of MPNP.