Since the 1960s, Côte d'Ivoire has experienced a decline in forest areas in favor of humanized areas due to the establishment of cash and food crops. The Nassian sub-prefecture is not on the sidelines of this degradation. The objective of this research is to analyze the land use and the impact of anthropogenic activities on the natural environment in the Nassian sub-prefecture from 1998 and 2018. The methodology was based on a cartographic, analytical approach. based on the use of remote sensing and geographic information systems (GIS). Carrying out this study required the use of satellite and cartographic data and field surveys. The results indicate a transformation of natural spaces by human activities. Thus, the sub-prefecture initially made up of forests and savannahs deteriorated in favor of humanized areas (crops / fallow, habitats / bare soil) from 1998 to 2018. The analysis indicates that from 1998 to 2018, the transformation of the environment is changing at a rapid pace. There is a regression of natural spaces in favor of humanized spaces. Natural areas have gone from 64% to 37%. Humanized spaces have progressed at the expense of natural spaces. They went from 36% to 63% from 1998 to 2018. We are witnessing human pressure on the environment and degradation of the plant cover.