In Morocco, according to WHO estimates, the prevalence rate of diabetes in the adult population is 12.4%. This pathology is the cause of more than 12,000 deaths per year. Glycemic control prevents the progression of most complications. Currently, glycated hemoglobin (HbA1c) is the most relevant biological marker for monitoring diabetic patients. The objective of this work is to study the correlation between HbA1c and fasting blood sugar (G0) in diabetic patients at the CHI Ibn Rochd in Casablanca. Fasting blood glucose was sampled on a dry tube and analyzed on the Alinity ® Abbott automaton by an enzymatic method using Hexokinase. The HbA1c assay, taken on tri-potassium EDTA, was carried out by High Performance Liquid Chromatography (HPLC) on an ADAMS TM A1c HA-8180v automaton. Statistical analysis was performed using SPSS software. The correlation between HbA1c and G0 was positive with the Pearson correlation coefficient at r=0.69 and P < 0.001. A 1% rise in the HbA1c value would correspond approximately to a 0.69 g/l rise for the G0 found from the regression curve equation: HbA1C= 4.680 + 1.458 x G0. Our study found a good correlation between fasting blood glucose and HbA1c in Moroccan diabetic adults, which could be useful in clinical practice for better control of glycemic balance.

Introduction: Glycogen storage disease type I is a rare hereditary metabolic disorder, caused by a deficit of the glucose-6-phosphatase, an enzyme that catalyzes hydrolysis of glucose-6-phosphate to phosphate and glucose, inducing essentially hypoglycemia, hyperlactacidemia, hyperuricemia and hyperlipoproteinemia often at the expense of triglycerides. Hypertriglyceridemia is often moderate (<10 g / l) at the time of diagnosis, but in the long term, it can exceed 20g/l causing serious complications such as acute pancreatitis or hepatic adenoma. We report a case of glycogen storage disease type I revealed by major hypertriglyceridemia.Case report: A 10-month-old infant girl, with a family history of storage disease type I (brother), admitted to the pediatric department for recurrent seizures due to hypoglycemia evolving for 2 months, and hepatomegaly. The blood tests made on admission revealed a hepatic cytolysis with a liver enzyme level 5 times upper the limit of normal, a major hypertriglyceridemia at 10 g / l (<1.5 g / l), and a correct glycemia and uricaemia. The infant was put on an adequate diet therapy. The evolution was marked by good clinical improvement.Conclusion: Major hypertriglyceridemia is a metabolic abnormality often occurring during the course of glycogen storage disease type I, but sometimes it is discovered at the time of diagnosis requiring prompt management and strict monitoring to avoid complications.