A descriptive study was conducted at the Office of the Provincial Division of Health of South Ubangi to assess the level of knowledge of the agents there affect on health problems related to the computer. The main concern was to determine the level of the agents on the pathologies related to the use of the computer.The survey was conducted with a population of 40 agents, from which we extracted a sample of 35 agents present and having the computer as a working tool and this in the period from January 15 to March 15, 2018. The latter has led the following results: knowledge of health problems related to the use of the computer gave, based on observed frequencies, 36%.This result being lower than our acceptability criterion, led to the conclusion that the agents of the Provincial Division of Health of South Ubangi have little knowledge of health problems related to the use of the computer.