Aeromonas hydrophila subsp. Dhakensis a causative agent of gastroenteritis disease present in Diarrheal faeces. Computational research for peptide vaccine against aeromonal protein has been Published. In this study, the complete genome sequence of a virulent Aeromonas hydrophila strain was retrieved from genomic database. We screened the genome and identify the protein which was least similar to the human. Antigen determinant peptide was predicted with different databases and ASA calculation. Identified antigen was designed 3D model and simulation was performed in discovery studio from the docking study. We identify LATL determinant were the best peptide having CDocker energy 76.1367Kcal/mol. As this peptide was transmembrane protein it can be best potential vaccine.
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