Volume 46, Issue 1, December 2019, Pages 1–9
Evance Okumu Seko1, Vincent Omondi Were2, Alice Charity Awinja3, Dan Onguru4, and Amolo Stephen Asito5
1 Department of TB/HIV Operations Research, Medical Research Institute, Center for Global Health and Research, P.O Box 1578-40100 Kisumu, Ken, Kenya
2 Department of Statistics and Data management, Medical Research Institute, Center for Global Health and Research, P.O BOX 1578-40100 Kisumu, Ken, Kenya
3 Department of Health Promotion, Adaptive Management and Research Consultancy, P.O. Box 5022-40141 Kisumu, Kenya
4 School of Health Sciences, Jaramogi Oginga Odinga University of Science and Technology, Bondo, P.O BOX 210-40601 Bondo, Kenya
5 School of Biological and physical sciences, Jaramogi Oginga Odinga University of Science and Technology, P.O Box 210-40601 Bondo, Kenya
Original language: English
Copyright © 2019 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Despite scaling up Isoniazid preventive therapy implementation in areas with a high prevalence of HIV and latent tuberculosis infection >30%, there is a paucity of data assessing adherence which is pivotal to END TB control and elimination. We sought to determine the adherence level and its correlates among people living with HIV initiated on IPT in selected hospitals in Kisumu Central, Kisumu County. Methods: A facility-based cross-sectional study was conducted at Jaramogi Oginga Teaching and Referral Hospital, Kisumu County Hospital and Lumumba Sub-County Hospital between June and July 2018. A random sample of PLHIVs aged ≥18 years, initiated on IPT between 2016 and 2018 were interviewed. Self-reported method was used to ascertain adherence. Data was collected using Commcare and analysed with STATA 14.0. A generalized linear regression model was used to generate the adjusted prevalence ratios and 95% confidence intervals. Results: Of 462 respondents, 282(61%) were females. The mean age of respondents was 37.9 [±10.4, SD]. Forty percent (40% [n=185; 95 C.I = (35.6%-44.6%) adhered to treatment. Respondents who had knowledge of latent tuberculosis infection were more likely to adhere compared to those who had no knowledge [aPR=1.6; 95%CI= (1.16-2.2), P=0.004]. Respondents who experienced IPT stock-outs were less likely to adhere as compared to those who experienced no stock-outs [aPR=0.15; 95%CI= (0.02-0.93); P=0.042]. Conclusion: The overall adherence level is sub-optimal against a set threshold (≥ 80%). Knowledge and IPT stock-outs were associated with adherence. Sustained awareness campaigns and uninterrupted supply of IPT would optimize on adherence.
Author Keywords: Adherence, Treatment, latent, tuberculosis, Infection.
Evance Okumu Seko1, Vincent Omondi Were2, Alice Charity Awinja3, Dan Onguru4, and Amolo Stephen Asito5
1 Department of TB/HIV Operations Research, Medical Research Institute, Center for Global Health and Research, P.O Box 1578-40100 Kisumu, Ken, Kenya
2 Department of Statistics and Data management, Medical Research Institute, Center for Global Health and Research, P.O BOX 1578-40100 Kisumu, Ken, Kenya
3 Department of Health Promotion, Adaptive Management and Research Consultancy, P.O. Box 5022-40141 Kisumu, Kenya
4 School of Health Sciences, Jaramogi Oginga Odinga University of Science and Technology, Bondo, P.O BOX 210-40601 Bondo, Kenya
5 School of Biological and physical sciences, Jaramogi Oginga Odinga University of Science and Technology, P.O Box 210-40601 Bondo, Kenya
Original language: English
Copyright © 2019 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Despite scaling up Isoniazid preventive therapy implementation in areas with a high prevalence of HIV and latent tuberculosis infection >30%, there is a paucity of data assessing adherence which is pivotal to END TB control and elimination. We sought to determine the adherence level and its correlates among people living with HIV initiated on IPT in selected hospitals in Kisumu Central, Kisumu County. Methods: A facility-based cross-sectional study was conducted at Jaramogi Oginga Teaching and Referral Hospital, Kisumu County Hospital and Lumumba Sub-County Hospital between June and July 2018. A random sample of PLHIVs aged ≥18 years, initiated on IPT between 2016 and 2018 were interviewed. Self-reported method was used to ascertain adherence. Data was collected using Commcare and analysed with STATA 14.0. A generalized linear regression model was used to generate the adjusted prevalence ratios and 95% confidence intervals. Results: Of 462 respondents, 282(61%) were females. The mean age of respondents was 37.9 [±10.4, SD]. Forty percent (40% [n=185; 95 C.I = (35.6%-44.6%) adhered to treatment. Respondents who had knowledge of latent tuberculosis infection were more likely to adhere compared to those who had no knowledge [aPR=1.6; 95%CI= (1.16-2.2), P=0.004]. Respondents who experienced IPT stock-outs were less likely to adhere as compared to those who experienced no stock-outs [aPR=0.15; 95%CI= (0.02-0.93); P=0.042]. Conclusion: The overall adherence level is sub-optimal against a set threshold (≥ 80%). Knowledge and IPT stock-outs were associated with adherence. Sustained awareness campaigns and uninterrupted supply of IPT would optimize on adherence.
Author Keywords: Adherence, Treatment, latent, tuberculosis, Infection.
How to Cite this Article
Evance Okumu Seko, Vincent Omondi Were, Alice Charity Awinja, Dan Onguru, and Amolo Stephen Asito, “Predictors of adherence to Isoniazid Preventive Therapy among people living with HIV: A cross-sectional study in Kisumu Central, Western Kenya,” International Journal of Innovation and Scientific Research, vol. 46, no. 1, pp. 1–9, December 2019.
