Volume 18, Issue 2, October 2015, Pages 224–231
André Gilles Mache1, Valentin Désiré GUIAMA2, and Carl Moses F. Mbofung3
1 Department of Food Sciences and Nutrition, National School of Agro-Industrial Sciences, University of Ngaounderé, P.O Box : 455 Ngaounderé, Cameroun
2 Department of Food Science and Nutrition, The University of Ngaoundere, National School of Agro-industrial Sciences, PO BOX 455, Ngaoundere, Cameroon
3 Department of Food Science and Nutrition, The University of Ngaoundere, National School of Agro-industrial Sciences, PO BOX 455, Ngaoundere, Cameroon
Original language: English
Copyright © 2015 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Tea extracts are used in many over-the-counter preparations claiming to promote weight loss. The rationale for this usage includes reports that khaya extract inhibit the digestion/absorption of carbohydrate and fat into gastrointestinals tube of rats. The investigators in this study tested the potential of increasing doses of three extracts concentrations (3.3mg/Kg of khaya tea, 6.6mg/Kg of khaya tea, and 9.9mg/Kg of khaya tea) to induce weight loss, steatorrhea, and blood lipid alterations in rats ingesting a high-fat diet. During the 90 days on the HFD, the animals were treated with 3.3mg/Kg, 6.6mg/Kg and 9.9mg/Kg of body weight of khaya tea. The time course of the body weight and obesity-related biochemical parameters were evaluated. The animals were fed with a standard diet (SD, n= 6) or high-fat diet (HFD, n= 6) for 90 days. After 90 days of treatment with 3.3mg/Kg, 6.6mg/Kg and 9.9mg/Kg of body weight, Khaya tea suppressed the increases average 37.43% of the changes in body weight gain (expressed as % of initial body weight) (P< 0.05) and decreased the serum triglycerides and low-density lipoprotein (LDL)-cholesterol concentrations at both doses (from 69±2 to 50.3 ±2.7 mg/dL, from 27±1 to 23.5 ±1 mg/dL; P< 0.05, respectively) after they had been increased by the HFD. The abdominal lipids content was also decreased by the diet containing khaya tea (from 7.30 ±0.11 to 5.52 ±0.16 mg/dL; P< 0.05). These results suggest that khaya tea could be a potentially therapeutic alternative in the prevention of obesity caused by a HFD.
Author Keywords: KHAYA senegalensis, Khaya Tea, anti-hyperlipidemic effect, anti-weight gain effect, bioactives components (phenols and polyphenols) of KT, High-Fat-Diet (HFD) rats.
André Gilles Mache1, Valentin Désiré GUIAMA2, and Carl Moses F. Mbofung3
1 Department of Food Sciences and Nutrition, National School of Agro-Industrial Sciences, University of Ngaounderé, P.O Box : 455 Ngaounderé, Cameroun
2 Department of Food Science and Nutrition, The University of Ngaoundere, National School of Agro-industrial Sciences, PO BOX 455, Ngaoundere, Cameroon
3 Department of Food Science and Nutrition, The University of Ngaoundere, National School of Agro-industrial Sciences, PO BOX 455, Ngaoundere, Cameroon
Original language: English
Copyright © 2015 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Tea extracts are used in many over-the-counter preparations claiming to promote weight loss. The rationale for this usage includes reports that khaya extract inhibit the digestion/absorption of carbohydrate and fat into gastrointestinals tube of rats. The investigators in this study tested the potential of increasing doses of three extracts concentrations (3.3mg/Kg of khaya tea, 6.6mg/Kg of khaya tea, and 9.9mg/Kg of khaya tea) to induce weight loss, steatorrhea, and blood lipid alterations in rats ingesting a high-fat diet. During the 90 days on the HFD, the animals were treated with 3.3mg/Kg, 6.6mg/Kg and 9.9mg/Kg of body weight of khaya tea. The time course of the body weight and obesity-related biochemical parameters were evaluated. The animals were fed with a standard diet (SD, n= 6) or high-fat diet (HFD, n= 6) for 90 days. After 90 days of treatment with 3.3mg/Kg, 6.6mg/Kg and 9.9mg/Kg of body weight, Khaya tea suppressed the increases average 37.43% of the changes in body weight gain (expressed as % of initial body weight) (P< 0.05) and decreased the serum triglycerides and low-density lipoprotein (LDL)-cholesterol concentrations at both doses (from 69±2 to 50.3 ±2.7 mg/dL, from 27±1 to 23.5 ±1 mg/dL; P< 0.05, respectively) after they had been increased by the HFD. The abdominal lipids content was also decreased by the diet containing khaya tea (from 7.30 ±0.11 to 5.52 ±0.16 mg/dL; P< 0.05). These results suggest that khaya tea could be a potentially therapeutic alternative in the prevention of obesity caused by a HFD.
Author Keywords: KHAYA senegalensis, Khaya Tea, anti-hyperlipidemic effect, anti-weight gain effect, bioactives components (phenols and polyphenols) of KT, High-Fat-Diet (HFD) rats.
How to Cite this Article
André Gilles Mache, Valentin Désiré GUIAMA, and Carl Moses F. Mbofung, “ANTI-HYPERLIPIDEMIC AND ANTI-WEIGHT GAIN EFFECTS OF KHAYA TEA ON HIGH-FAT-DIET RATS,” International Journal of Innovation and Scientific Research, vol. 18, no. 2, pp. 224–231, October 2015.
