Volume 12, Issue 1, November 2014, Pages 126–134
Md. Shamim Hossain1 and Md. Ashrafuzzaman Sapon2
1 Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia-7003, Bangladesh
2 Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia-7003, Bangladesh
Original language: English
Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The fruit fly, Drosophila melanogaster, has been used to analyze genetics, development, and signaling for nearly a century. About 60% of the genes that are believed to cause human disease have found to a recognizable match in the genetic code of the common fruit fly (Drosophila melanogaster), and 50% of Drosophila's protein sequences are similar to those of mammals. Fruit flies are mostly used in disease analysis of human because their gene and protein similarities are included in an organism with only four pairs of chromosomes, the X/Y sex chromosomes and three autosomes, numbered 2, 3 and 4. The advantages of using Drosophila are that they breed and mature rapidly, are inexpensive and easy to grow, produce several hundred offspring per generation, and need very little space. The fruit fly is also an ideal candidate for human disease studies because simple mutations cause obvious phenotype differences and its genome map has been fully sequenced.
Author Keywords: Drosophila, model, human disease, genetic.
Md. Shamim Hossain1 and Md. Ashrafuzzaman Sapon2
1 Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia-7003, Bangladesh
2 Department of Biotechnology and Genetic Engineering, Faculty of Applied Science and Technology, Islamic University, Kushtia-7003, Bangladesh
Original language: English
Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The fruit fly, Drosophila melanogaster, has been used to analyze genetics, development, and signaling for nearly a century. About 60% of the genes that are believed to cause human disease have found to a recognizable match in the genetic code of the common fruit fly (Drosophila melanogaster), and 50% of Drosophila's protein sequences are similar to those of mammals. Fruit flies are mostly used in disease analysis of human because their gene and protein similarities are included in an organism with only four pairs of chromosomes, the X/Y sex chromosomes and three autosomes, numbered 2, 3 and 4. The advantages of using Drosophila are that they breed and mature rapidly, are inexpensive and easy to grow, produce several hundred offspring per generation, and need very little space. The fruit fly is also an ideal candidate for human disease studies because simple mutations cause obvious phenotype differences and its genome map has been fully sequenced.
Author Keywords: Drosophila, model, human disease, genetic.
How to Cite this Article
Md. Shamim Hossain and Md. Ashrafuzzaman Sapon, “Drosophila as a Model for Analyzing of Human Genetic and Pathogenic Related Diseases,” International Journal of Innovation and Scientific Research, vol. 12, no. 1, pp. 126–134, November 2014.
