Chronic Stress plays a significant role in the progression of tumor angiogenesis through the secretion of Catecholamines, which take part in increased production of IL-6 & VEGF. Chronic psychological stress induces secretion of catecolamines such as epinephrine (E) & noreepinephrine (NE) from adrenal medulla & sympathetic neurons which activate β-adrenergic receptors on tumor cells, which in turn enhances increased production of IL-6. IL-6 then plays a significant role in VEGF production through STAT3 activation. Il-6 follows a series of signaling cascades including cAMP/PKA & MAPK. NF-kB activation through MEK/ERK is crucial for IL-6 production. Angiogenesis, the formation of new blood vessels from preexisting vasculatures is mediated by VEGF. It also takes part in cell proliferation, cell migration & vasculogenesis, thus leading to tumor angiogenesis. The aim of this study was to know the relationship between chronic stress and tumor angiogenesis and to highlight the therapeutic point where further works may proceed on.

Use of plant based drugs and chemicals for curing various ailments and personal adornment is as old as human civilization. Plants and plant-based medicaments are the basis of many of the modern pharmaceuticals we use today for our various ailments. The aim of the study was to evaluate the antimicrobial activity of Barringtonia acutangula (Family: Lecythidaceae) and Premna corymbosa (Family: Verbenaceae), two widely distributed shrubs of the Sundarbans mangrove forest by disc diffusion assay. The in vitro antimicrobial activity was tested against E. coli, S. flexneri, S. dysenteriae, V. cholerae , S. paratyphi, Proteus spp, S. aureus and S. epidermis using disc diffusion assay where the chloroformic extract of bark of B. acutangula showed excellent performance against E. coli and the zone of inhibition was recorded as 10mm and 13mm for 500µg and 1000µg consistently. The chloroformic extracts of bark of P. corymbosa also showed significant activity against V. cholera, S. dysenteriae and E. coli respectively. In this investigation Kanamycin (30 µg / disc) standard disc were used as the reference.