H5P is an artificial intelligence software that comprises learning content such as presentations, quizzes, interactive videos, and games. This study scrutinizes the role of using H5P in the enhancement of the ESP English Vocabulary of Moroccan Higher Education Students. Based on a convenient sampling and a triangulation model of analysis, one hundred and seventy-five students from the High School of Technology in Khenifra were tested and observed while fifteen teachers were interviewed. The aim of this quasi-experimental study is to analyze the importance of incorporating H5P as an innovative AI synchronously and asynchronously to enrich EST students’ ESP vocabulary, which supports language skills mainly writing and speaking. The participants attended different ESP activities using the H5P platform, and the project lasted ten weeks. The data collected were supported by the SPSS software and analyzed to identify the effects of H5P on the participants’ impetus and ESP improvement. The outcome also displays that working with H5P during a short period had a relatively significant impact on students’ learning sustainability which can empower their language knowledge. Analyses of the questionnaires’ responses prior to and after the exposure to H5P reveal the latter significantly contributes to students’ ESP vocabulary enhancement. Indeed, the research seeks an alternate teaching approach that would assist students in widening their English vocabulary through novel AI platforms. Teachers may indeed generate novel pedagogies from this paper’s outcome. The ultimate results imply that H5P contributes to enriching EFL students’ lexicon.