Global and regional climate simulation results often do not accurately reflect changes in climate, hampering their direct applicability. Impact studies using high-resolution data received bias correction for climate variables. This study made it possible to choose and validate regional climate models from the CORDEX-Africa database in order to describe the future climate of the Sassandra River watershed in Buyo (western Côte d’Ivoire). The choice of models was made by the Taylor diagram method associated with the seasonal profile of the models and observations. Thus, the outputs of the selected models were corrected by the Distribution Mapping method (quantile mapping) using the CMhyd tool. At the end the potential future climate changes are assessed by analyzing the changes predicted by the models. The study reveals that the ICHEC, IPSL and NCC models have a good ability to simulate the climate of the basin. The climate simulation shows variations in climate parameters. The RCP 4.5 scenario forecasts rainfall fluctuations of -20.8% to +58.1% by 2030 and from -18.8% to +61.7% by 2050. The RCP 8.5 predict precipitation fluctuations of -19.4% to +43.8% by 2030 and -7.5% to +73.3% by 2050. All models include an increase in temperature under the two scenarios from +1.6 to +4.4℃ for RCP 4.5 and from +2.1 to +5℃ for RCP 8.5.