[ Anémie hémolytique auto-immune associée à un myélome multiple ]
Volume 66, Issue 2, May 2023, Pages 317–320
Naoual Hasnaoui1, Nadia Tazi2, and Fatima Zahra Belhoussine3
1 Department of Clinical Hematology, Hassan II Oncology Centre, Oujda, Morocco
2 Cabinet d’Anatomie Pathologique, Rabat, Morocco
3 Service de Radiologie, Clinique Achifaa, Oujda, Morocco
Original language: French
Copyright © 2023 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Autoimmune hemolytic anemia (AHAI) is rarely associated with multiple myeloma (MM), may be present at diagnosis or during disease progression, and its pathogenic mechanisms remain unclear. We report the case of a 57-year-old insulin-treated diabetic patient admitted for severe autoimmune hemolytic anemia with warm IgG antibodies. Serum protein electrophoresis revealed a monoclonal IgG lambda protein, urine immunofixation showed a lambda light chain, and the bone marrow was 25% infiltrated with plasma cells. Corticosteroid therapy in combination with treatment for multiple myeloma resulted in remission of the anemia. Although rare, AHAI should be considered in MM patients with severe anemia and frequent transfusion requirements.
Author Keywords: Multiple myeloma, autoimmune hemolytic anemia.
Volume 66, Issue 2, May 2023, Pages 317–320
Naoual Hasnaoui1, Nadia Tazi2, and Fatima Zahra Belhoussine3
1 Department of Clinical Hematology, Hassan II Oncology Centre, Oujda, Morocco
2 Cabinet d’Anatomie Pathologique, Rabat, Morocco
3 Service de Radiologie, Clinique Achifaa, Oujda, Morocco
Original language: French
Copyright © 2023 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Autoimmune hemolytic anemia (AHAI) is rarely associated with multiple myeloma (MM), may be present at diagnosis or during disease progression, and its pathogenic mechanisms remain unclear. We report the case of a 57-year-old insulin-treated diabetic patient admitted for severe autoimmune hemolytic anemia with warm IgG antibodies. Serum protein electrophoresis revealed a monoclonal IgG lambda protein, urine immunofixation showed a lambda light chain, and the bone marrow was 25% infiltrated with plasma cells. Corticosteroid therapy in combination with treatment for multiple myeloma resulted in remission of the anemia. Although rare, AHAI should be considered in MM patients with severe anemia and frequent transfusion requirements.
Author Keywords: Multiple myeloma, autoimmune hemolytic anemia.
Abstract: (french)
L’anémie hémolytique auto-immune (AHAI) est rarement associée au myélome multiple (MM), peut être présente au moment du diagnostic ou au cours de la progression de la maladie, et ses mécanismes physiopathologique ne sont toujours pas clairs. Nous rapportons le cas d’un patient diabétique de 57 ans, traité à l’insuline, admis pour une anémie hémolytique auto-immune sévère avec des anticorps IgG chauds. L’électrophorèse des protéines sériques a révélé une protéine monoclonale IgG lambda, l’immunofixation des urines a mis en évidence une chaîne légère lambda, et la moelle osseuse était infiltrée à 25 % par des plasmocytes. La corticothérapie associée au traitement du myélome multiple a permis une rémission de l’anémie. Bien que rare, l’AHAI doit être évoquée chez les patients atteints de MM présentant une anémie sévère et des besoins transfusionnels fréquents.
Author Keywords: Myélome multiple, anémie hémolytique auto-immune.
How to Cite this Article
Naoual Hasnaoui, Nadia Tazi, and Fatima Zahra Belhoussine, “Autoimmune hemolytic anemia associated with multiple myeloma,” International Journal of Innovation and Scientific Research, vol. 66, no. 2, pp. 317–320, May 2023.
