[ Activité antiplasmodiale des plantes médicinales d’Afrique de l’Ouest: Revue de la littérature ]
Volume 28, Issue 2, January 2017, Pages 121–129
Kodjovi AGBODEKA1, Holaly E. Gbekley2, Simplice D. KAROU3, Kokou ANANI4, and Jacques Simpore5
1 Centre de recherche et de Formation sur les Plantes Médicinales, Université de Lomé, Togo, Togo
2 Centre de recherche et de Formation sur les Plantes Médicinales, Université de Lomé, Togo
3 Centre de recherche et de Formation sur les Plantes Médicinales, Université de Lomé, Togo de Recherche Biomoléculaire Pietro Annigoni, Ouagadougou, Togo
4 Centre de recherche et de Formation sur les Plantes Médicinales, Université de Lomé, Togo
5 Centre de Recherche Biomoléculaire Pietro Annigoni, Ouagadougou, Burkina Faso
Original language: French
Copyright © 2017 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Until now, malaria remains a major public health problem in the intertropical zone. There is an urgent need to identify new anti-malarial drug targets, due to the increasing problem of drug resistance to malaria parasites. Historically, the majority of antimalarial drugs have been derived from medicinal plants or from structures modelled on plant lead compounds. In various West African countries, several plants have been reported to be having antimalarial effects and are being applied traditionally as antimalarial agents. This review focuses on medicinal plants which are used to treat malaria in West Africa during the period of 2003 to 2015. It also attempts to describe some tests which can be used to evaluate plant extracts for antimalarial activity. One hundred and forty-six herbal plants have been captured in this article due to their local usage as antimalarial agents. Some like Acanthosermum hispidum D.C., Icacina senegalensis, Pavetta crassipes, Croton labatus, show intense activity against malaria parasites in vitro and in experimentally infected mice. The array of medicinal plants employed as antimalarial agents in West Africa, unveils a promising source for the development of new and better antimalarial drugs. It is vital that the efficacy and safety of traditional medicines be validated and their active constituents be identified in order to establish reliable quality control measures.
Author Keywords: Ethnomedecine, Plasmodium, antimalarial, Selectivity index, Croton labatus.
Volume 28, Issue 2, January 2017, Pages 121–129
Kodjovi AGBODEKA1, Holaly E. Gbekley2, Simplice D. KAROU3, Kokou ANANI4, and Jacques Simpore5
1 Centre de recherche et de Formation sur les Plantes Médicinales, Université de Lomé, Togo, Togo
2 Centre de recherche et de Formation sur les Plantes Médicinales, Université de Lomé, Togo
3 Centre de recherche et de Formation sur les Plantes Médicinales, Université de Lomé, Togo de Recherche Biomoléculaire Pietro Annigoni, Ouagadougou, Togo
4 Centre de recherche et de Formation sur les Plantes Médicinales, Université de Lomé, Togo
5 Centre de Recherche Biomoléculaire Pietro Annigoni, Ouagadougou, Burkina Faso
Original language: French
Copyright © 2017 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Until now, malaria remains a major public health problem in the intertropical zone. There is an urgent need to identify new anti-malarial drug targets, due to the increasing problem of drug resistance to malaria parasites. Historically, the majority of antimalarial drugs have been derived from medicinal plants or from structures modelled on plant lead compounds. In various West African countries, several plants have been reported to be having antimalarial effects and are being applied traditionally as antimalarial agents. This review focuses on medicinal plants which are used to treat malaria in West Africa during the period of 2003 to 2015. It also attempts to describe some tests which can be used to evaluate plant extracts for antimalarial activity. One hundred and forty-six herbal plants have been captured in this article due to their local usage as antimalarial agents. Some like Acanthosermum hispidum D.C., Icacina senegalensis, Pavetta crassipes, Croton labatus, show intense activity against malaria parasites in vitro and in experimentally infected mice. The array of medicinal plants employed as antimalarial agents in West Africa, unveils a promising source for the development of new and better antimalarial drugs. It is vital that the efficacy and safety of traditional medicines be validated and their active constituents be identified in order to establish reliable quality control measures.
Author Keywords: Ethnomedecine, Plasmodium, antimalarial, Selectivity index, Croton labatus.
Abstract: (french)
Le paludisme reste un problème majeur de santé publique dans la zone intertropicale. En raison du problème de plus en plus croissant de la résistance du Plasmodium aux antipaludiques classiques, il y a urgence de découvertes de nouvelles molécules. Historiquement, la majorité de ces médicaments est synthétisée à partir de plantes médicinales ou calquées sur les structures de leurs composés. Dans divers pays Ouest Africain, plusieurs plantes ont été signalés à avoir des effets antipaludiques et sont utilisées traditionnellement comme antipaludiques. Cette revue recense et analyse les différentes publications relatives aux plantes médicinales ayant une activité antiplasmodiale en Afrique de l'Ouest au cours de la période de 2003 à 2015. Il tente également de mettre en exergue quelques tests utilisés pour évaluer des extraits de ces plantes. Cent quarante-six plantes médicinales ont été répertoriées. Certains, comme Acanthospermum hispidum D.C., Icacina senegalensis, Pavetta crassipes, Croton labatus, montrent une intense activité contre le plasmodium in vitro et chez des souris infectées expérimentalement. La gamme de plantes médicinales employées comme antipaludiques en Afrique de l'Ouest, dévoile une source prometteuse pour le développement de nouveaux et de meilleurs médicaments antipaludiques. Il est essentiel que l'efficacité et l'innocuité de ces médicaments traditionnels soient validées et leurs constituants actifs identifiés afin d'établir des mesures de contrôle de qualité fiables.
Author Keywords: Ethnomedecine, Plasmodium, antipaludique, Indice de sélectivité, Croton labatus.
How to Cite this Article
Kodjovi AGBODEKA, Holaly E. Gbekley, Simplice D. KAROU, Kokou ANANI, and Jacques Simpore, “Antimalarial activity of medicinal plants from West Africa: A review,” International Journal of Innovation and Scientific Research, vol. 28, no. 2, pp. 121–129, January 2017.
